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Gastroprotective activity of hot ethanolic extract Alpinia calcarata rhizome in rats

Authors:

L. S. R. Arambewela,

Industrial Technology Institute, Bauddhaloka Mawatha, Colombo, LK
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L. D. A. M. Arawwawala,

Industrial Technology Institute, Bauddhaloka Mawatha, Colombo, LK
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W. D. Ratnasooriya

University of Colombo, Colombo, LK
About W. D.
Department of Zoology
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Abstract

A study to evaluate the gastroprotective activity of hot ethanolic extract (HEE) of Alpinia calcarata Roscoe (Zingiberaceae) rhizomes was carried out in rats. Three doses (500,750,1000 mg/kg) of HEE were evaluated for gastroprotective activity against ethanol induced gastric ulcers. Oral administration of HEE provided dose dependent and significant (P< 0.05) protection against gastric damage caused by ethanol. The gastroprotective effect of HEE was superior than cimetidine, the reference drug. HEE had strong antihistamine and antioxidant activities, which could have played an active role in inducing gastroprotection. HEE was devoid of unacceptable side effects: no overt signs of toxicity, hepatotoxicity, renotoxicity or haemotoxicity were observed up to 42 days. However, the weight of the spleen was increased in treated groups possibly indicating lymphoproliferative activity. It is concluded that HEE of A.calcarata rhizome has gastroprotective activity in rats. No immediate dose related serious toxicity was observed.
How to Cite: Arambewela, L.S.R., Arawwawala, L.D.A.M. & Ratnasooriya, W.D., (2005). Gastroprotective activity of hot ethanolic extract Alpinia calcarata rhizome in rats. Ceylon Journal of Medical Science. 48(1), pp.1–11. DOI: http://doi.org/10.4038/cjms.v48i1.4838
Published on 24 Jun 2005.
Peer Reviewed

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