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A simple cost-effective screening test for microalbuminuria

Authors:

H. Peiris ,

University of Sri Jayewardenepura, Nugegoda, LK
About H.
Department of Biochemistry
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A. A. P. Keerthi,

University of Sri Jayewardenepura, Nugegoda, LK
About A. A. P.
Department of Biochemistry
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U. C. L. Hewage,

University of Sri Jayewardenepura, Nugegoda, LK
About U. C. L.
Department of Medicine, Faculty of Medical Sciences
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D. J. S. Fernando

University of Sri Jayewardenepura, Nugegoda, LK
About D. J. S.
Department of Medicine, Faculty of Medical Sciences
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Abstract

Estimation of urinary albumin excretion in micro quantities requires expensive immunochemical methods which are not freely available in developing countries with limited resources. A study was performed to set up a simple cost-effective test to quantitatively assess the microalbuminuria. Urine specimens (173 samples) were collected and albumin concentration was estimated by precipitating with 25% sulphosalicylic acid (SSA) and use of a light dependent resistor (LDR) system. As the sensitivity of LDR system was interfered by the colour pigment of urine, all samples were run through a Sephadex G-25 micro column to separate the colour pigment. The present test detects albumin concentrations in the range 10-200 mg/L with a sensitivity and specificity values of 83 and 79% respectively. We conclude that the present LDR micro column gel filtration method can be used as a cost -effective screening test for microalbuminuria in developing countries.
How to Cite: Peiris, H. et al., (2003). A simple cost-effective screening test for microalbuminuria. Ceylon Journal of Medical Science. 46(2), pp.73–81. DOI: http://doi.org/10.4038/cjms.v46i2.4850
Published on 20 Dec 2003.
Peer Reviewed

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