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A comparative study of the protection offered by Vitamin E and Captopril, when used as additives in kidney storage solutions

Authors:

S. Selliah ,

University of Kelaniya, LK
About S.
Senior Lecturer, Department of Physiology, Faculty of Medicine
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A. De Tissera,

Medical Research Institute, Colombo 8, LK
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Pathologist
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T. De Mel

Ministry of Education, Colombo, LK
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Secretary
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Abstract

The demand for organ transplantation has stimulated a search for optimal methods of cadaveric kidney preservation techniques. The basis of development of these methods depends on an understanding of cellular metabolic function during the period of storage and the changes confronting the organ during reperfusion. Free radicals are implicated in both these phenomena. Consequently agents that are capable of combating free radical attack (free radical scavengers/antioxidants) are now being investigated more extensively, with the hope of providing better posttransplant organ function.

 

This study has attempted to answer the question whether better organ preservation and post transplant viability could be achieved with kidney storage solutions containing the antioxidants vitamin E or angiotensin converting enzyme (ACE) inhibitors. Post-storage viability of kidney tissue was assessed by assessing renal functions in isolated perfused animal kidneys. The isolated perfused kidney (TPK) model was used to test renal function such as glomerular filtration rate, sodium and glucose reabsorption and protein excretion after the organs were stored in solutions containing vitamin E or captopril. These results were also correlated with the ultrastructural appearances of the kidney tissue.

 

The findings of this study suggest that inclusion of vitamin E into the storage solutions offered protection to the renal tissue. This was shown by improved renal function of the kidneys stored in solutions containing vitamin E. Electron microscopic studies further strengthened these findings. However the study using ACE inhibitor captopril failed to show similar results.
How to Cite: Selliah, S., De Tissera, A. & De Mel, T., (2001). A comparative study of the protection offered by Vitamin E and Captopril, when used as additives in kidney storage solutions. Ceylon Journal of Medical Science. 44(1), pp.11–18. DOI: http://doi.org/10.4038/cjms.v44i1.4868
Published on 28 Jun 2001.
Peer Reviewed

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