Start Submission Become a Reviewer

Reading: Extra-pancreatic effects contributing to the hypoglycaemic activity of Artocarpus heterophyllus

Download

A- A+
dyslexia friendly

Original Articles

Extra-pancreatic effects contributing to the hypoglycaemic activity of Artocarpus heterophyllus

Authors:

M. R. Fernando ,

University of Sri Jayewardenepura, Gangodawila, Nugegoda, LK
About M. R.
Department of Microbiology, Faculty of Medical Sciences
X close

M. I. Thabrew

University of Kelaniya, Talagolla Road, Ragama, LK
About M. I.
Department of Biochemistry and Clinical Chemistry
X close

Abstract

Investigations were carried out to determine whether the aqueous leaf extract of Artocarpus heterophyllus has extra-pancresatic effects which may contribute towards the observed hypoglycaemic activity of the leaf extract in rats. Administration of the leaf extract prior to glucose loading resulted in a significantly increased glycogen content in the liver (by 70%) and muscle (by 100%) and the triacylglycerol content in the adipose tissue (by 30%) in comparison with rats treated only with the glucose load. The leaf extract was also able to markedly inhibit the activity of insulinase. Pretreatment of fasted rats with the leaf extract of Artocarpus heterophyllus had no significant effect on the gluconeogenic capacity of kidney slices. Similar results were obtained with kidney slices pre-incubated with aqueous leaf extract of Artocarpus heterophyllus. The leaf extract had no effect on the intestinal glucose absorption.
How to Cite: Fernando, M.R. & Thabrew, M.I., (2001). Extra-pancreatic effects contributing to the hypoglycaemic activity of Artocarpus heterophyllus. Ceylon Journal of Medical Science. 44(1), pp.1–10. DOI: http://doi.org/10.4038/cjms.v44i1.4867
Published on 28 Jun 2001.
Peer Reviewed

Downloads

  • PDF (EN)

    comments powered by Disqus