Introduction: Pseudoexfoliation glaucoma (PXG) is a secondary, open angle glaucoma, subject to wide geographical variation. It is a progressive disease without cure, and treatment is directed at control of intraocular hypertension.
Objectives: To determine the prevalence and icharacteristics and to evaluate the hypotensive response to differing types of treatment, on pseudoexfoliation glaucoma (PXG).
Methods: The study consists of 342 patients with PXG, detected among a 2083 glaucoma clinic population, during a five year period. Clinical features were recorded and patients subjected to initial medical therapy. The non-responders at the end of 12 to 16 weeks of treatment had trabeculectomy (n=42) or combination of trabeculectomy, lens extraction and intraocular lens implant - triple procedure (n=145).
Results: The prevalence of PXG in the glaucoma population was 16.4%. Notable features were: high incidence of unilaterality (71.6%) and lens opacification (60%). The success rate of treatment (restoration of normal intraocular pressure) at the end of 12 to 16 months oftreatment were as follows: medical 21%, triple procedure 61%, and trabeculectomy 80% (p < 0.001). Postoperative complications were high in triple procedure due to associated cataract extraction (p < 0.001).
Conclusion: The prevalence of PXG was relatively high. Trabeculectomy offers the best results.
Studies are required to portray the cause of the disease, to effect cure and or arrest its progression.